Women have a certain ovarian reserve when they are born and the number of eggs gradually decreases through both ovulation and cell death (atresia). Menopause takes the scene when the ovarian reserves deplete. Average age of menopause is 51. “Early menopause” implies menopause that happens before 45 years of age. On the other hand, “primary ovarian insufficiency” (POI) is a condition characterized by cessation of periods before 40s.

While no exact cause is identified in some cases of early menopause or primary ovarian insufficiency, an underlying cause is detected in others. Some of these cases are as follows:

• Family history
• Smoking
• Chemotherapy/radiotherapy
• Surgical removal of ovaries
• Some autoimmune diseases
• HIV and AIDS
• Some chromosomal disorders
• Chronic fatigue syndrome

Early menopausal women with pregnancy plan are challenging cases for In Vitro Fertilization physicians. The literature did not recommend a treatment option for these patients until near past, while a recent discovery, PRP injection to ovaries (ovarian rejuvenation), is a promising treatment for these patients and in vitro fertilization doctors. However, patient selection is very crucial, as this treatment does not help all patients. At our hospital, PRP is injected to ovaries of patients who require this treatment.