Yeditepe University Hospitals Orthopedics and Traumatology Specialist Assoc. Prof. Dr. Koray Başdelioğlu answered the questions of how bone metastasis occurs, whether bone metastasis gives any symptoms, and whether any cancer metastasizes to the bone.
What Is Bone Metastasis?
Bone metastasis is the formation of a cancerous mass settling in the bone through various complex mechanisms of cancer that occurs in any organ in the body.
Which Cancers Most Commonly Metastasize to Bone?
Every cancer has the potential to metastasize to the bone. But most commonly, breast and prostate cancers metastasize to the bone. Less frequently, lung cancer, thyroid cancer, bladder cancer, kidney cancer, and colorectal cancer are among the cancers that can metastasize to the bone.
Are Bone Metastases Common?
Bone metastasis is a very common problem. According to some studies, it is the most common site for metastases, while according to some studies, it is the third most common site for metastasis after lung and liver metastases. In autopsy studies, it was determined that 70% of breast and prostate cancer patients and 35-42% of lung, thyroid, and kidney cancer patients had bone metastases. In addition, the incidence of bone metastases is increasing as a result of the increase in survival with new treatments.
In Which Bones Do Bone Metastases Occur Most? Is There a Reason for This?
Although bone metastases can be seen in any bone, they are most common in the spine, pelvis, and thigh bone close to the hip. The main reason for the more frequent occurrence of bone metastases in these regions is that these are regions where the bone marrow is more active and the extensive venous networks around the spine.
How Does Bone Metastasis Occur?
There are quite complex mechanisms in the formation of bone metastases. The main factor is the microenvironment of the tumor. Cancer cells that come to the bone by leaving main cancer as a result of various mechanisms and signals try to adapt to this new microenvironment. Cancer cells that come to the bone plant the seeds of bone metastasis by premetastatic niche, a process called osteomimicry, in which they imitate bone cells. Interestingly, these cancer cells that settle in the bone may be in a low-proliferation or dormant state until a signal is received that triggers activation. When they start to proliferate, they first form micrometastases that cannot be detected, and then bone metastases that can be clinically revealed.
What Are the Symptoms of Bone Metastases?
It may not be noticed in cases where it does not cause clinical symptoms or routine follow-up is not made. It may present with conditions such as pain, pathological fracture, hypercalcemia, and spinal cord compression.
How is a Patient with Bone Metastases Treated?
The clinical condition of the patient, the number and location of metastases, and the life expectancy are the factors taken into consideration for treatment. In the treatment of bone metastasis, surgery, radiotherapy, various drugs, thermal ablation, electrochemotherapy, and MRI-guided high-intensity focused ultrasound can be used.
”
İlgili Yazılar
- Is Cancer a Treatable Disease?
- What Causes Shoulder Dislocation? Shoulder Dislocation Treatment
- Knee Pain
- Wrist Pain Causes and Treatment
- Ergonomics in Automobiles Prevents Accidents
- Nutrition in Cancer
- Cancer Treatment Methods
- Don't Underestimate Bone Pain That Doesn't Make You Sleep and Doesn't Relieve With Medication
- Is Lymphoma (Lymph Cancer) a Treatable Disease?
- Joint Pain and Causes of Joint Pain
- Walking and Returning to Social Life After Knee Replacement Surgery
- What Are the Advantages of Robotic Knee Replacement Surgery?
- Robotic Knee Prosthesis Surgery
- Why Does Ankle Pain Occur? What Is the Treatment?
- What Causes Hip Pain? How Does Hip Pain Go Away?
- The Usage Area of Robotic Surgery Expands in Orthopedic Surgeries
- Higher Risk of Anterior Cruciate Ligament and Ankle Injury in Female Athletes
- Prof. Dr. Gökhan Meriç:Patients Who Undergo Joint Replacement Surgery Can Stand Up and Walk the Next Day
- Spinal Fractures
- Big Toes Can Be A Big Problem!
- Can Weight Loss Despite Not Dieting Be a Sign of Cancer?
- Treatments that Reduce Life Loss in Cancer Give Hope!
- What is Synovitis in Joints?
- Hip Osteoarthritis and Hip Prosthesis
- Hip Impingement Syndrome
- What is the Future of Treating Cartilage Problems?
- Not Only Athletes Suffer from Meniscus Tears!
- Is Cartilage Damage More Common in Those Who Run for Long Periods?
- Beware If Your Shoulder Or Neck Pain Lasts Longer Than Two Days After Swimming!
- Mistakes While Swimming Can Cause Shoulder Pain
- What is a Stress Fracture? How to Treat Stress Fracture?
- Wear Heeled Shoes Against Heel Spurs
- Improper Use of Phones, Tablets and Computers Increases Elbow Pain
- Does Your Shoulder Strain When Lifting Your Arm?
- Myths About Fractures
- Endocrine Disease May Also Be the Cause of Bone, Joint, and Muscle Pain
- Be Careful in the First 24 Hours of Hip Fractures!
- Vitamin D Deficiency May Be The Cause Of Your Joint Pain
- The First Onset of Pain in Cartilage Damage in the Knee Should Not Be Overlooked
- Have Your Baby Take Their First Steps in Good Health
- Heavy School Bags Can Cause Pain in the Lower Back, Shoulders, and Hands!
- Sports Injuries
- Cartilage Transplantation from Donor Has Been Started to Perform in Turkey
- Knee and Hip Arthroplasty Boosts Quality of Life
- What Should Be Considered In Preventing Home Accidents For The Elderly?
- Choose Proven Treatments, Not Alternative Methods in Cancer Treatment!
- Beware Information Pollution About Cancer!
- Is Hot Chemotherapy the New Hope for Advanced Stage Cancer Patients?
- No Obstacle to Having Screening Tests in Gynecological Cancers
- Good Results have been Achieved in Leukemia Treatment
- Do Individualized Treatments Offer Hope for Cancer?
- Early Detection Is Cancer's Most Powerful Enemy
- Working From Home Increases Waist and Neck Problems
- He Walked Out Of The Hospital Where He Entered On Crutches
- The Number of Completely Cured Cancer Types is Increasing Day by Day
- While Cancer Occurrences Increase, Life Expectancy Also Increases
- First Cartilage Transplant from a Donor
- The Hope of ‘Immunotherapy’ in Advanced-Stage Cancer Treatment
- Pay Attention to the Pain That Occurs in the Front Part of Your Knees While Playing Sports!
- Cancer Statistics Reveal the Importance of Protecting Against Cancer
- New Research Points to the Important Issues in Breast Cancer
- 8 Common Misconceptions About Sports Injuries
- Found Out That She Had Cancer After Her Accident, and Immunotherapy Was Her Solution!
- Breast MRI
- Breast Ultrasound
- Mammography
- Side Effects of Chemotherapy and Coping Methods
- Hot Chemotherapy (HIPEC)
- Young Patient Who Could Not Walk Due to Cartilage Damage Recovered With Cartilage Transplantation
- What Is a Fracture and How Is It Treated?
- False Facts in Cancer
- Knee Arthritis
- Stem Cell Therapy in Orthopedic Diseases
- 3-Dimensional Diagnostic Method in Breast Tumors: TOMOSYNTHESIS
- Cancer and Exercise
- Curiosities About Breast Cancer
- Dancing with Cancer
- Lung Cancer
- Most Common Cancers
- Biopsy for Bone and Soft Tissue Tumors
- Bone Metastasis
- Important Warning from The Expert: “Not Every Large Tumor is Advanced Cancer”
- Knee Pain
- Common Misconceptions About Cancer
- Surgery for Breast Cancer and Breast Aesthetics Can Be Performed Simultaneously
- Beware of New Moles and Non-Healing Wounds
- 6 Problems Causing Pain in the Feet
- 60 Percent of Shoulder Pain Complaints are Caused by Shoulder Impingement
- Meniscus Tear Warning from a Specialist: Beware of Sports Grounds!
- Crunching in the Kneecap May Be a Sign of Calcification
- Protective Equipment Required When Using Electric Scooters
- Injured Athletes Can Return To Sports With Cartilage Transplant
- New Treatment Approaches Promising in Metastatic Breast Cancer
- Treatment of Knee Arthrosis Varies According to the Person
- A Lack of Attention to Sports Injuries in Children May Affect Their Development
- Insidious Danger of Pathological Fractures Increase in Recent Years